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EC number: 215-202-6 | CAS number: 1313-13-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not conducted to GLP but follows basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Particles and SO2 - Synergistic effects for pulmonary damage
- Author:
- Rylander R and Bergström R
- Year:
- 1 973
- Bibliographic source:
- Proceedings of the 3rd International Clean Air Congress, PA23-A25
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The effect of MnO2 on the respiratory tract was investigated by exposing guinea pigs for 28 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Manganese dioxide
- EC Number:
- 215-202-6
- EC Name:
- Manganese dioxide
- Cas Number:
- 1313-13-9
- Molecular formula:
- MnO2
- IUPAC Name:
- manganese dioxide
- Details on test material:
- - Name of test material (as cited in study report): manganese dioxide
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- other: conventional and infection controlled animals were used
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet: ad libitum
- Water: tap water
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Remarks on MMAD:
- MMAD / GSD: > 0.5 µm < 5.0 µm
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: MnO2 dust was generated in a Rag Pe aerosol generator.
- Air change rate: 4 air changes per hour.
- Method of particle size determination: Royco Model 225 particle counter was used. At 20mg MnO2/m³ approx 600 000 particles per minute were found to be >0.5µm and <5.0µm in diameter. - Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- No data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20 mg/m3
Basis:
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Exposure to MnO2 caused a slight increase in the number of macrophages in the infection controlled group. The number of leukocytes was increased in both types of Guinea-pig. MnO2 caused a slight increase in the irritation score when compared to controls. This was more apparent in infection controlled animals.
Applicant's summary and conclusion
- Conclusions:
- Effects of MnO2 on the infection controlled group were not observed in the normal animals.
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