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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically defensible or guideline method was used, no GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Guideline:
other: US Federal Hazardous Sustances Act
Deviations:
not specified
Remarks:
for further details, see below
Principles of method if other than guideline:
0.5 g applied as finely ground sample moistened with water
Study was conduced according to Federal Hazardous Substance Act
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Carboxylic acids, di-, C4-6
EC Number:
271-678-5
EC Name:
Carboxylic acids, di-, C4-6
Cas Number:
68603-87-2
Molecular formula:
C5H8O4, C4H6O4, C6H10O4
IUPAC Name:
68603-87-2
Details on test material:
Dibasic Acid Concentrate; 0.5 g applied as finely ground sample moistened with water

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
water
Controls:
not required
Duration of treatment / exposure:
24 hours
Observation period:
7 days
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
1.2
Max. score:
4
Reversibility:
fully reversible
Remarks:
within 168 h
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48 and 168 h
Score:
0.43
Max. score:
4
Reversibility:
fully reversible
Remarks:
within 72 h
Other effects:
Slight scabbing at lines of abrasions.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
not irritating