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Short-term toxicity to fish

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The acute toxicity of Carboxylic acids, di-,C4-C6 to fish (Brachydanio rerio) was conducted in a static mortality test similiar to OECD Guideline 203 (Fish, Acute Toxicity Test). After 96 hours of exposure a LC50 of 59.5 mg/L (geometric mean) was obtained (Bayer, 1988).

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Additional information

There are two tests on toxicity to fish available.

The dicarboxylic acids are of weak to medium acidity and partly dissociate in water causing a pH shift (pKa1: 4.21-4.43; pKa2: 5.42-5.64). The tolerance of water organisms towards pH is diverse. Recommended pH values for test species listed in OECD guidelines are between 6 and 9.

In an acute test performed with Leuciscus idus according to the German national standard method DIN 38412 Part 15 a 96 h-LC50 of > 147 mg/l for the mixture with following composition: 24-28% adipic acid, 40-45% glutaric acid, 28-33% succinic acid was obtained (BASF, 1980). At test concentrations above 220 mg/l used in the aquatic toxicity test the pH shifts to <6. At 147 mg/L no effect was observed. At higher concentrations some mortalities occurred, along with reduced pH (below pH 4.5). As effect of pH allone at higher concentrations is unclear, as a precautionary approach the LC50 was assumed to be > 147 mg/L. This assumption is confirmed by a test carried out in neutralised test solution at a concentration of 686 mg/L where no effects were observed.

The acute toxicity of Carboxylic acids, di-,C4-C6 to fish (Brachydanio rerio) was conducted in a static mortality test similiar to OECD Guideline 203 (Fish, Acute Toxicity Test). After 96 hours of exposure a LC50 of 59.5 mg/L (geometric mean) was obtained in buffered medium (Bayer, 1988). The test substance was a residue from adipic acid manufacturing containing the following composition: 60 % adipic acid, 14 % glutaric acid, 6 % succinic acid, 10 % carbon, 6.5 % vanadium pentoxide, 3 % copper nitrate and 5 % copper.