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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically defensible or guideline method was used, no GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Animals were dosed with 40% aqueous solutions for 24 hours and observed for 14 days.
one female rabbit was dosed with 5010 mg/kg.
one female and 1 male rabbit was dosed with 7940 mg/kg
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Carboxylic acids, di-, C4-6
EC Number:
271-678-5
EC Name:
Carboxylic acids, di-, C4-6
Cas Number:
68603-87-2
Molecular formula:
C5H8O4, C4H6O4, C6H10O4
IUPAC Name:
68603-87-2
Details on test material:
Dibasic acid concentrate

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Duration of exposure:
24 hours
Doses:
5010 and 7940 mg/kg
No. of animals per sex per dose:
5010 group: one female
7940 mg/kg group: one female and one male
Control animals:
not required

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD0
Effect level:
7 940 mg/kg bw

Any other information on results incl. tables

Signs of intoxication: wieght loss (two to four days)

Gross autopsy: viscera appeared normal

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD0 > 7940 mg/kg
Executive summary:

No mortality was reported in an acute dermal toxicity experiment in rabbits following administration of 5010 mg/kg (n=1) or 7940 mg/kg (n=2) of a 40% aqueous solution/suspension of dicarboxylic acid mixture. The only clinical signs reported were weight loss during the first 2 to 4 days. The viscera appeared normal at termination after 14 days.