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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP, short documentation, no data on humidity during the exposure

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Test type:
other: Similar to OECD TG 403

Test material

Constituent 1
Chemical structure
Reference substance name:
Adipic acid
EC Number:
204-673-3
EC Name:
Adipic acid
Cas Number:
124-04-9
Molecular formula:
C6H10O4
IUPAC Name:
adipic acid
Details on test material:
Test substance purity 99.8%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
nose/head only
Remarks:
INA 20 system, BASF;  animals were sitting in tubes and the mouth protruded into the inhalation  chamber; It is unclear whether the eyes of the animals were exposed  also. 
Vehicle:
other: dust
Duration of exposure:
4 h
Concentrations:
7.7 and 5.4 mg/l
No. of animals per sex per dose:
20
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
7.7 mg/L air
Exp. duration:
4 h

Any other information on results incl. tables

Neither mortality nor symptoms were observed during and after exposure. No pathological changes were reported at necropsy.

Applicant's summary and conclusion

Executive summary:

In a study similar to OECD TG 403, neither mortality, toxic symptoms nor macroscopic pathological changes were observed in 20 rats exposed for 4 hours (nose/head only) to the maximal attainable concentration of 7700 mg/m3 of adipic acid (99.8 %) dust. 50 % of the particles had a MMAD below 3.5 µm (BASF 1981).