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Partition coefficient

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Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
Cited as Directive 92/69/EEC, A.8
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
-2.1
Temp.:
23 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
-1.9
Temp.:
23 °C
pH:
5
Key result
Type:
log Pow
Partition coefficient:
-2.3
Temp.:
23 °C
pH:
9
Conclusions:
The log10 partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)
Executive summary:

The log10 partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
30/04/2007
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
other: atomic emission spectroscopy (in duplicate)
Key result
Type:
log Pow
Partition coefficient:
< -1.8
Temp.:
20 °C
pH:
6.5

Flask

pH in water phase

water phase

n-octanol phase

log Pow

1:1

6.5

0.766 mg/mL

<0.012 mg/mL

<-1.8

1:2

6.5

0.773 mg/mL

<0.012 mg/mL

<-1.8

2:1

6.6

0.850 mg/mL

<0.012 mg/mL

<-1.9

The substance was below the limit of detection in the octanol phase. As the concentration was 0.01 M in the water phase, it is not possible to increase the amount of the substance.

Conclusions:
The log10 partition coefficient of sodium formate at 20 °C was measured to be -1.8 (1:1 water octanol ratio), 1.8 (1:2 water octanol ratio), 1.9 (2:1 water octanol ratio).
Executive summary:

The log10 partition coefficient of sodium formate at 20 °C was measured to be -1.8 (1:1 water octanol ratio), 1.8 (1:2 water octanol ratio), 1.9 (2:1 water octanol ratio).

Endpoint:
partition coefficient
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
When added to water both formic acid and sodium formate have similar dissociation constants and will form identical formate ions. Thus a partition coefficient study performed on formic acid will sufficiently address the data requirements of sodium formate.
Reason / purpose for cross-reference:
read-across source
Key result
Type:
log Pow
Partition coefficient:
-2.1
Temp.:
23 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
-1.9
Temp.:
23 °C
pH:
5
Key result
Type:
log Pow
Partition coefficient:
-2.3
Temp.:
23 °C
pH:
9
Conclusions:
The log10 partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)
Executive summary:

The log10 partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)

Description of key information

The log10 partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.1
at the temperature of:
20 °C

Additional information