Registration Dossier
Registration Dossier
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EC number: 205-488-0 | CAS number: 141-53-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- Secondary source (ECB IUCLID 2000). The full report was not available for review.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Smith EN and Taylor RT
- Year:
- 1 982
- Bibliographic source:
- Toxicology 25, 271-287. Cited in: ECB IUCLID 2000.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium formate
- EC Number:
- 205-488-0
- EC Name:
- Sodium formate
- Cas Number:
- 141-53-7
- Molecular formula:
- CHO2Na
- IUPAC Name:
- sodium formate
- Details on test material:
- Assumingly Sodium Formate.
Constituent 1
- Specific details on test material used for the study:
- Assumingly Sodium Formate.
Test animals
- Species:
- mouse
- Strain:
- C57BL
Administration / exposure
- No. of animals per sex per dose:
- 12
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- >= 3 700 - <= 4 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Mice fed with a folic acid supplemented diet showed a slightly higher LD50 (4700 mg/kg) than mice fed a diet without folic acid supplements (LD50 3700 mg/kg)
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Mice fed with a folic acid supplemented diet showed a slightly higher LD50 (4700 mg/kg) than mice fed a diet without folic acid supplements (LD50 3700 mg/kg).
- Executive summary:
In a non-standard study, mice fed with a folic acid supplemented diet showed a slightly higher LD50 (4700 mg/kg bw) than mice fed a diet without folic acid supplements (LD50 3700 mg/kg bw).
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