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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Secondary source (ECB IUCLID 2000). The full report was not available for review.

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Smith EN and Taylor RT
Year:
1982
Bibliographic source:
Toxicology 25, 271-287. Cited in: ECB IUCLID 2000.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium formate
EC Number:
205-488-0
EC Name:
Sodium formate
Cas Number:
141-53-7
Molecular formula:
CHO2Na
IUPAC Name:
sodium formate
Details on test material:
Assumingly Sodium Formate.
Specific details on test material used for the study:
Assumingly Sodium Formate.

Test animals

Species:
mouse
Strain:
C57BL

Administration / exposure

No. of animals per sex per dose:
12

Results and discussion

Effect levels
Key result
Dose descriptor:
LD50
Effect level:
>= 3 700 - <= 4 700 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mice fed with a folic acid supplemented diet showed a slightly higher LD50 (4700 mg/kg) than mice fed a diet without folic acid supplements (LD50 3700 mg/kg)

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Mice fed with a folic acid supplemented diet showed a slightly higher LD50 (4700 mg/kg) than mice fed a diet without folic acid supplements (LD50 3700 mg/kg).
Executive summary:

In a non-standard study, mice fed with a folic acid supplemented diet showed a slightly higher LD50 (4700 mg/kg bw) than mice fed a diet without folic acid supplements (LD50 3700 mg/kg bw).

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