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Registration Dossier
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EC number: 205-488-0 | CAS number: 141-53-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Only secondary literature (review,). Expousre route Meets generally accepted scientific standards, well documented and acceptable for assessment. This report was submitted to the committee of the Deutsche Forschungsgemeinschaft (DFG) assessing hazardous materials.
Data source
Reference
- Reference Type:
- publication
- Title:
- Die akute und chronische Toxizität der Ameisensäure und ihrer Formiate.
- Author:
- Malorny G
- Year:
- 1 969
- Bibliographic source:
- Zeitschrift Ernährungswissenschaft 9, 332-339.
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium formate
- EC Number:
- 205-488-0
- EC Name:
- Sodium formate
- Cas Number:
- 141-53-7
- Molecular formula:
- CHO2Na
- IUPAC Name:
- sodium formate
- Details on test material:
- Sodium Formate.
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intravenous
- No. of animals per sex per dose:
- 50
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 807 mg/kg bw
Any other information on results incl. tables
RS-Freetext:
LD50 of formic acid and its salts in the mouse following
i.v. injection:
===========================================================
Substance LD50 range LD50 No. of
(formate #) animals
(mg/kg bw) (mg/kg bw) n
-----------------------------------------------------------
Formic acid 145 138-151 142 50
Na-formate 807 800-813 534 50
K-formate 95 93-97 51 55
NH4-formate 410 408-412 293 50
Ca-formate 154 150-158 107 55
===========================================================
# = calculated proportion of formate of the LD50 dose.
Applicant's summary and conclusion
- Conclusions:
- The i.v. LD50 of sodium formate was approx. 807 mg/kg bw in mice.
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