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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Only secondary literature (review,). Expousre route Meets generally accepted scientific standards, well documented and acceptable for assessment. This report was submitted to the committee of the Deutsche Forschungsgemeinschaft (DFG) assessing hazardous materials.

Data source

Reference
Reference Type:
publication
Title:
Die akute und chronische Toxizität der Ameisensäure und ihrer Formiate.
Author:
Malorny G
Year:
1969
Bibliographic source:
Zeitschrift Ernährungswissenschaft 9, 332-339.

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium formate
EC Number:
205-488-0
EC Name:
Sodium formate
Cas Number:
141-53-7
Molecular formula:
CHO2Na
IUPAC Name:
sodium formate
Details on test material:
Sodium Formate.

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intravenous
No. of animals per sex per dose:
50

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
807 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
LD50 of formic acid and its salts in the mouse following
i.v. injection:

===========================================================
Substance      LD50      range        LD50           No. of
                                    (formate #)     animals
                 (mg/kg bw)         (mg/kg bw)          n
-----------------------------------------------------------
Formic acid    145      138-151        142             50
Na-formate     807      800-813        534             50
K-formate       95       93-97          51             55
NH4-formate    410      408-412        293             50
Ca-formate     154      150-158        107             55 
===========================================================
# = calculated proportion of formate of the LD50 dose.

Applicant's summary and conclusion

Conclusions:
The i.v. LD50 of sodium formate was approx. 807 mg/kg bw in mice.

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