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EC number: 252-104-2 | CAS number: 34590-94-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1951
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted prior to GLP and guidelines but the report contains sufficient data to permit a meaningful evaluation of study results.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Dipropylene glycol methyl ether (Dowanol 50B) was tested for skin irritation and skin sensitization potential on human subjects
- GLP compliance:
- no
- Remarks:
- Study was conducted prior to GLP
- Type of study:
- other: study on human subjects
- Species:
- human
- Sex:
- male/female
- Details on test animals and environmental conditions:
- not applicable
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- not specified in the report
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- not specified in the report
- No. of animals per dose:
- not applicable
- Details on study design:
- The undiluted Dowanol 50B was applied to the backs of 200 unselected human subjects (100 males and 100 females) and allowed to remain in direct contact with the skin for a period of 5 days. At the end of this period, the patches were removed and any irritation noted. Three weeks later, Dowanol 50B was applied again to the backs of the same subjects and allowed to remain in contact with the skin for a period of 48 hours.
In another additional test, Dowanol 50B was tested by a repeated insult method on 50 unselected human subjects (25 males and 25 females). Dowanol 50B was applied to the backs of the subjects for 4-8 hours every other day until 10 applications were made. After a lapse of 3 weeks, the material was reapplied for a period of 24-48 hours. - Statistics:
- not specified in the report
- Reading:
- other: Human patch test: The material was applied to the back of each subject for 4 to 8 hours every other day until 10 applications had been made. After a lapse of 3 weeks, the material was reapplied for a period of 24 to 48 hours.
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 50
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: Human patch test: The material was applied to the back of each subject for 4 to 8 hours every other day until 10 applications had been made. After a lapse of 3 weeks, the material was reapplied for a period of 24 to 48 hours.. . Hours after challenge: 24.0. Group: test group. Dose level: 100%. No with. + reactions: 0.0. Total no. in groups: 50.0.
- Reading:
- other: Human patch test: The material was applied to the back of each subject for 4 to 8 hours every other day until 10 applications had been made. After a lapse of 3 weeks, the material was reapplied for a period of 24 to 48 hours.
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 50
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: Human patch test: The material was applied to the back of each subject for 4 to 8 hours every other day until 10 applications had been made. After a lapse of 3 weeks, the material was reapplied for a period of 24 to 48 hours.. . Hours after challenge: 48.0. Group: test group. Dose level: 100%. No with. + reactions: 0.0. Total no. in groups: 50.0.
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- In conclusion DOWANOL 50B (DPGME) was classified as neither a primary skin irritant nor a skin sensitizer as none of the human subjects exhibited any evidence of irritation during the study.
- Executive summary:
Undiluted DPGME was applied to the backs of 200 unselected human subjects, 100 males and 100 females, and allowed to remain in direct contact with the skin for 5 days. Three weeks later, DPGME was again applied to the backs of the same subjects and allowed to remain in contact with the skin for a period of 48 hours.
DPGME was tested by a repeated insult method on 50 unselected human subjects, 25 males and 25 females. The material was applied to the back of each subject for 4 to 8 hours every other day until 10 applications had been made. After a lapse of 3 weeks, the material was reapplied for a period of 24 to 48 hours.In conclusion DPGME (DOWAMOL 50B) was classified as neither a primary skin irritant nor a skin sensitizer as none of the human subjects exhibited any evidence of irritation during the study.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a human patch test dipropylene glycol methyl ether was applied undiluted to the backs of 200 unselected human subjects (100 males and 100 females). In an additional study, dipropylene glycol methyl ether was tested by a repeated insult method on 50 unselected human subjects (25 males and 25 females). Based on the results of these studies dipropylene glycol methyl ether was classified as neither a primary skin irritant nor a skin sensitizer as none of the human subjects exhibited any evidence of irritation or sensitization during the study.
Migrated from Short description of key information:
Dipropylene glycol methyl ether (Dowanol 50B) was tested for skin irritation and skin sensitization potential in a human volunteer study.
Justification for selection of skin sensitisation endpoint:
This human volunteer study was conducted prior to GLP and guidelines but the report contains sufficient data to permit a meaningful evaluation of study results.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
No studies on respiratory sensitization are available for dipropylene glycol methyl ether. Based on structure activity relationship with other glycol ethers and absence of skin sensitising potential, genotoxicity and irritancy, dipropylene glycol methyl ether is not expected to be a respiratory tract sensitiser.
Justification for classification or non-classification
No sensitization reaction was observed with dipropylene glycol methyl ether in the study with human volunteers. According to EU criteria for classification and labelling requirements for dangerous substances as laid down in Annex VI of the EEC Council Directive 671548lEEC (amended by Directive 83/467/EEC), dipropylene glycol methyl ether is not classified as a skin or a respiratory sensitiser.
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