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EC number: 252-104-2
CAS number: 34590-94-8
out of 7 lithographers using DPGME, ethylene glycol monoethyl ether, and
a range of aliphatic, aromatic and halogenated hydrocarbons for offset
and ultraviolet-cured multicoloured printing, showed normal peripheral
blood parameters; however, bone marrow specimens showed stromal injury.
It is unlikely that DPGME caused the observed effects. DPGME was present
along with substituted benzenes, chlorinated solvents, n-propanol, and
EGEE in workplace solutions. Suspicion of DPGME as a causal agent came
from personal, area air samples and wipe samples. The most intense
exposure to DPGME was from an ultraviolet curing wash and air sampling
revealed 0.6 to 6.43 ppm air concentrations.
The authors of this article provide limited and inconclusive data that
DPGME may be the cause of bone marrow injury in a small group of exposed
lithographers. Because of the small group studied, it is difficult to
causally link occupational exposure with the marrow lesions. This is
further confounded by a lack of published data regarding the prevalence
of such marrow injury parameters in workers or the general population.
Besides the hypothesis that DPGME may play a role in the observed
injury, the authors also suggest that it is plausible that marrow
changes represent the result of ubiquitous insults from infectious
agents, drugs, alcohol, or other environmental agents or unknown factors.
The most convincing evidence that DPGME is not responsible for such
effects comes from a lack of recorded marrow effects in other
subchronically and chronically tested PGE's (PGME, PGtBE). This is in
contrast to EGME. DPGME itself when applied dermally up to 10 g/kg for
90 days produced no hematologicaleffects even though mortality was high
at the 10 g/kg level.
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