(2-methoxymethylethoxy)propanol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1961

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted prior to Guidelines/GLP. The report contains sufficient information to permit a meaningful evaluation of study results.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1961

Report date:

1961

Reference 2

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

Smyth, H.F., Carpenter, C.P., Weil, C.S. et al.

Year:

1962

Bibliographic source:

Published in Am Ind Hyg Assoc J. 23: 95-107.

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Test type:

other: Range Finding study

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

(2-methoxymethylethoxy)propanol

EC Number:

252-104-2

EC Name:

(2-methoxymethylethoxy)propanol

Cas Number:

34590-94-8

Molecular formula:

C7H16O3

IUPAC Name:

2-[(1-methoxypropan-2-yl)oxy]propan-1-ol

Details on test material:

- Name of test material (as cited in study report): Monomethyl Ether of Dipropylene Glycol

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: The rabbits were procured locally and maintained on Rockland Rabbit station
- Age at study initiation: 3 to 5 months of age
- Weight at study initiation: 2.5 kg

Administration / exposure

Type of coverage:

not specified

Vehicle:

other: Vinylite sheeting

Details on dermal exposure:

The fur was removed from the entire trunk by clipping and the dose was retained an impervious plastic film (VINYLITE sheeting). Rabbits were immobilizes during the 24-hour skin contact period. Thereafter, VINYLITE sheeting was removed and the animals were caged for the remainder of the 14-day observation period.

Duration of exposure:

24 hour

Doses:

20, 10 and 5 ml/kg

No. of animals per sex per dose:

4 males per dose level

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: No
See the table attached below for more details.

Statistics:

The moving average method of calculating the LD50 was used.

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

10 mL/kg bw

Remarks on result:

other: (6.8-14.8 ml/kg bw)

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

9 510 mg/kg bw

Mortality:

20 ml/kg-4/4
10 ml/kg-2/4
5 ml/kg-0/4

Clinical signs:

other: Marked erythema of the skin was found upon removal of the impervious plastic covering after the 24-hour contact.

Gross pathology:

At autopsy, gross observation disclosed some consolidation and congestion of the lungs, dark mottled livers with prominent acini, and very pale smooth-textured kidneys.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The test material is not classified according to EU criteria as LD50 value is greater than 2000 mg/kg BW.

Executive summary:

Monomethyl ether of Dipropylene Glycol was evaluated for skin penetration in rabbits. Male albinostrain rabbits, three to five months of age and averaging 2.5 kg in weight, were immobilized during the 24-hour skin contact period. Thereafter, the VINYLITE sheeting used to retain the dose in contact with the clipped skin of the trunk was removed and the animals were caged for the remainder of the 14-day observation period. The rabbits were procured locally and maintained onrabbit station. The moving average method of calculating the LD50 was used.

 

Most deaths were delayed from three to four days after dosing. At autopsy, gross observation disclosed some consolidation and congestion of the lungs, dark mottled livers with prominent acini, and very pale smooth-textured kidneys.

 

The LD50 was calculated to be 10.0 (6.8 to 14.8) ml/kg. as received. Marked erythema of the skin was found upon removal of the impervious plastic covering after the 24-hour contact. All survivors gained weight during the two-week holding period. The test material was not classified as toxic according to EU criteria as LD50 was greater than 2000 mg/kg bw.