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EC number: 252-104-2
CAS number: 34590-94-8
rats (10/sex/exposure) were exposed to 0, 15, 50 and 200 ppm (0, 91, 303
and 1212 mg/m3) of dipropylene glycol monomethyl ether (DPGME) for 6
hr/day, 5 days /week for 13 weeks.
were no DPGME exposure related adverse effects on body weights in rats
during the 13 week study. There were no statistically significant
differences from control body weight means in male and female rats. There
were no exposure related effects on any of the measured hematology
parameters in either sex of rat. There were also no statistically
significant differences from control means. There
were no exposure related effects on any of the measured clinical
chemistry parameters in either sex of rat. The only statistically
significant difference was a slight decrease in BUN in female rats
exposed to 50 ppm, but this had no toxicological significance. There
were no apparent effects on any of the urinalysis parameters of male and
female rats. There
were also no statistically significant differences in absolute or
relative organ weights of rats exposed to DPGME, except for a slight
decrease in mean relative liver weight of 50 ppm exposed males.
gross and histopathologic observations were considered to be spontaneous
changes of minimal severity which were not treatment related. Based on
gross observations, liver from rats exposed to DPGME appeared to be
increased in size, however this observation was not supported by group
mean liver weights and there was no histopathologic evidence of
Based on the results of this study the NOAEL
for dipropylene glycol methyl ether for inhalation exposure of
Fischer-344 rats is 200 ppm.
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