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EC number: 252-104-2
CAS number: 34590-94-8
Groups of 32 to 37 bred Fischer 344 rats
were exposed via inhalation for 6 hours/day to 0 (control filtered air),
50, 150 and 300 ppm of DPGME vapors on day 6 through 15 of gestation.
In-life parameters examined included clinical observations, feed
consumption, water consumption and body weight. On day 21 of gestation,
all animals were euthanased prior to cesarean section. Maternal liver
and gravid uterine weights, the number of corpora lutea, implantations,
resorptions and live/dead fetuses were recorded. The fetuses were
removed from the uterus, weighed and examined for external, visceral and
skeletal alterations. No treatment-related effects were observed on any
of the maternal, embryonal and fetal parameters evaluated.
In conclusion, inhalation exposure of
pregnant rats to concentrations of DPGME as high as 300 ppm on days 6
through day 15 of gestation was not maternally toxic, embryo/fetotoxic
or teratogenic. Three hundred ppm was the highest concentration of DPGME
that was practically attainable at normal room temperature and pressure.
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