Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-104-2
CAS number: 34590-94-8
Several non-GLP studies in rats and dogs equivalent to OECD guidelines 401 are available for dipropylene glycol methyl ether. For the inhalation route three non-GLP studies in rats equivalent or similar to OECD guideline 403 are available. For the dermal route three non-GLP studies (one in rats and two in rabbits) equivalent or similar to OECD guideline 403 are available.
No mortalities (0/12) after 7-hour exposure to an atmosphere enriched with the test substance vapour at 20°C.
Majority of the acute toxicity studies
available for dipropylene glycol methyl ether were conducted prior to
GLP and OECD guidelines. However, the studies are well documented and
are considered to be reliable. Several independent studies are available
for each route of exposure reporting consistent results.
Oral - All acute toxicity studies via the
oral route reported LD50 values greater than 5000 mg/kg for dipropylene
glycol methyl ether. The key study identified for acute oral toxicity is the
BASF (1979) study in rats with a reported LD50 of greater than 5000 mg/kg
Inhalation - Via the inhalation route no
mortality was observed at the highest attainable concentration (i.e. LC0 values
> ca. 552.6 ppm, 3404.47 mg/m3) in three independent studies. The key study
identified is the BASF (1979) study in rats with a LC0 greater than 275 ppm
(duration 7 hours) which would be equivalent to approximately 1.69422 mg/l
(based on conversion equation at 20 degree celsius and 1 atmosphere). Using
Haber's law for converting this 7 -hour exposure to a 4 -hour exposure, the
equivalent LC0 value is greater than 2.04 mg/l or 2040 mg/m3.
Dermal - For the dermal route, two studies
reported no mortality up to the highest dose tested (20 ml/kg bw) in
rats and rabbits. One study in rabbits reported a dermal LD50 of 10
ml/kg bw (9510 mg/kg bw). The lowest LD50 will be taken into account for
the risk assessment. The key studies identified are the Dow/UCC (1961) study
in rabbits and the UCC (1961) study in rats with reported LD50 values of 9510
mg/kg body weight for rabbits and greater than 19020 mg/kg body weight in
LD50 values for oral and dermal route are
greater than 2000 mg/kg/bw. The LC0 value for inhalation is greater than
3404.47 mg/m3 (3.40447 mg/l), the highest attainable concentration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again