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EC number: 252-104-2
CAS number: 34590-94-8
DPGME was applied to the backs of 200 unselected human subjects, 100
males and 100 females, and allowed to remain in direct contact with the
skin for 5 days. Three weeks later, DPGME was again applied to the backs
of the same subjects and allowed to remain in contact with the skin for
a period of 48 hours.
was tested by a repeated insult method on 50 unselected human subjects,
25 males and 25 females. The material was applied to the back of each
subject for 4 to 8 hours every other day until 10 applications had been
made. After a lapse of 3 weeks, the material was reapplied for a period
of 24 to 48 hours.
conclusion DPGME (DOWAMOL 50B) was classified as neither a primary skin
irritant nor a skin sensitizer as none of the human subjects exhibited
any evidence of irritation during the study.
In a human patch test dipropylene glycol
methyl ether was applied undiluted to the backs of 200 unselected human
subjects (100 males and 100 females). In an additional study,
dipropylene glycol methyl ether was tested by a repeated insult method
on 50 unselected human subjects (25 males and 25 females). Based on the
results of these studies dipropylene glycol methyl ether was classified
as neither a primary skin irritant nor a skin sensitizer as none of the
human subjects exhibited any evidence of irritation or sensitization
during the study.
No sensitization reaction was observed with
dipropylene glycol methyl ether in the study with human volunteers.
According to EU criteria for classification and labelling requirements
for dangerous substances as laid down in Annex VI of the EEC Council
Directive 671548lEEC (amended by Directive 83/467/EEC), dipropylene
glycol methyl ether is not classified as a skin or a respiratory sensitiser.
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