Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-934-0 | CAS number: 1067-53-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no in vivo data on the toxicokinetics of tris(2-methoxyethoxy)vinylsilane. The following summary has therefore been prepared based on validated predictions of the physicochemical properties of the substance itself and its hydrolysis products. Tris(2-methoxyethoxy)vinylsilane is a moisture-sensitive, volatile liquid that hydrolyses in contact with water (half-life ca. 1 hour at pH 7), generating 2-methoxyethanol (ethylene glycol) and vinylsilanetriol. Human exposure can occur via the inhalation or dermal routes. Relevant inhalation and dermal exposure would be to the parent substance and hydrolysis products.
Absorption
Oral: Significant oral exposure is not expected for this substance.
Dermal: Dermal exposure would be to the parent and hydrolysis products. The molecular weights of tris(2-methoxyethoxy)vinylsilane and vinylsilanetriol are not ideal for dermal absorption, but they would not preclude it. The predicted water solubility (7.1E+4 mg/l) and predicted log Kow (0.26) of tris(2-methoxyethoxy)vinylsilane suggest that the amount of this parent substance that crosses the stratum corneum is very limited. The hydrolysis product has a high water solubility (1.0E+6 mg/l), and a log Kow of -2.0 and it is therefore not likely to be sufficiently lipophilic to cross the stratum corneum and therefore dermal absorption into the blood is likely to be low. There were no adverse systemic effects in dermal toxicity studies, and therefore no evidence of absorption.
Inhalation: The water solubility and log Kow of tris(2-methoxyethoxy)vinylsilane suggest that it will be dissolved in the mucous of the respiratory tract lining, but the log Kow is optimal for absorption, so it could be passively absorbed from the mucous. The hydrolysis product is also likely to be dissolved in mucous, but is significantly less likely to be absorbed. There are no reliable inhalation studies to check for evidence of absorption.
Distribution
The absorbed material is likely to be in the form of the parent and hydrolysis products, but overall is likely to be low. The log Kow of the parent substance means that it is likely to distribute into cells and the intracellular concentration might be higher than the extracellular concentration particularly in fatty tissues. The hydrolysis product is likely to be widely distributed in the blood, but the rate at which it diffuses across membranes might limit its distribution. Toxicity studies provide evidence for distribution to the lymphoid tissue.
Metabolism
There are no data on the metabolism of tris(2-methoxyethoxy)vinylsilane. However, it will continue to hydrolyse slowly to form 2-methoxyethanol and vinylsilanetriol once absorbed into the body. Genetic toxicity tests in vitro showed no observable differences in effects with and without metabolicactivation.
Excretion
Following dermal exposure, tris(2-methoxyethoxy)vinylsilane and vinylsilanetriol are likely to be sloughed off with skin cells. The high water solubility and low molecular weights of the parent and hydrolysis products mean that, once absorbed, they are likely to be excreted by the kidneys into urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live2