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EC number: 213-934-0 | CAS number: 1067-53-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
In the key acute oral toxicity study (WIL, 1999a), the LD50 for rats was determined to be >2000 mg/kg in a study that was carried out in accordance with OECD 401 and in compliance with GLP. A majority of the rats were noted with various discoloured areas due to discharges/excretions. Other findings in approximately one-third of the animals included abnormal excretion, hypoactivity and tremors. One male and one female died at the 2000 mg/kg dose level. Gastrointestinal abonormalities were detected at necropsy of one of the animals that died.
In the key acute dermal toxicity study (WIL, 1999b), the LD50 for rats was determined to be >2000 mg/kg in a study that was carried out in accordance with OECD 402 and in compliance with GLP. There were no clinical signs of toxicity or abormalities at necropsy, although local desquamation was observed.
Key value for chemical safety assessment
Additional information
The key acute oral and dermal studies were selected as the only available data for these endpoints that followed OECD test guidelines and were in compliance with GLP, and hence were assigned Reliability 2 (WIL, 1999a and WIL, 1999b). Two additional acute oral toxicity studies in rats were assigned Reliability 2 since they were not GLP and pre-dated the OECD guidelines. The LD50 was determined to be >2000 mg/kg in all cases.
A second acute dermal toxicity study in rabbits is available (Mellon, 1954), which gave an LD50 of ca. 1.5 ml/kg (equivalent to ca. 1545 mg/kg based on a density of 1.03 g/cm3). However, the more recent guideline study is used for classification purposes because the older study used occlusive coverings that resulted in necrosis of the skin, so subsequent deaths and other effects may have been secondary to corrosion.
Justification for classification or non-classification
On the basis of reliable data for the oral and dermal routes, tris(2 -methoxyethoxy)vinylsilane is not classified for acute toxicity according to EU Directive 67/548/EEC and Regulation 1272/2008.
No reliable data are available for the inhalation route.
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