Tris(2-methoxyethoxy)vinylsilane

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

3 March 1999 - 20 May 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Tris(2-methoxyethoxy)vinylsilane

EC Number:

213-934-0

EC Name:

Tris(2-methoxyethoxy)vinylsilane

Cas Number:

1067-53-4

Molecular formula:

C11H24O6Si

IUPAC Name:

ethenyl-tris(2-methoxyethoxy)silane

Test animals

Species:

rat

Strain:

other: Crl:CD(SD)IGS BR

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Laboratories Raleigh, NC
- Age at study initiation: 9-10 weeks (males), 10-11 weeks (females) old at initiation of dosing
- Weight at study initiation: 295-327 grams (males), 218 - 262 grams (females)
- Housing: individual suspended wire mesh cages
- Diet: PMI Nutrition International, Inc. Certified Rodent LabDiet 5002, ad libitum
- Water: reverse osmosis-treated municipal water, ad libitum
- Acclimation period: minimum of 7 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22.05-22.3 °C
- Humidity (%): 45-56.2 %
- Photoperiod (hrs dark / hrs light): 12 hours dark / 12 hours light

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: clipped dorsal skin
- % coverage: 18-23 %
- Type of wrap if used: the application area was overwrapped with gauze binders that were secured with nonirritating tape.

REMOVAL OF TEST SUBSTANCE
- Washing: the application sites were wiped with disposable paper towels moistened with tepid water.
- Time after start of exposure: 24 hours

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): The test article was dosed undiluted based on its specific gravity. The dose volume was determined by dividing the dose level (2000 mg/kg) by the specific gravity (1.05 g/mL). Individual doses were calculated based on body weights taken just prior to dosing and the dose volume of 1.90 mL/kg.

Duration of exposure:

24 hours

Doses:

2000 mg/kg bw/day

No. of animals per sex per dose:

5 males and 5 females

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

- Frequency of observations and weighing: Animals were observed for overt signs of toxicity at 1, 3, and 4 hours, and once daily thereafter, for a total of 14 days. Animals were observed twice daily for mortality. Body weights were recorded on days 0, 7 and 14.

- Necropsy of survivors performed: yes

- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Examination of the cranial, thoracic and abdominal cavities was carried out following termination.
  

Statistics:

No statistical analysis presented.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

There were no deaths.

Clinical signs:

other: Desquamation was noted sporadically during the study for five rats.

Gross pathology:

There were no remarkable gross necropsy findings.

Other findings:

There were no other test article related dermal findings.

Any other information on results incl. tables

The acute percutaneous LD₅₀ of tris(2-methoxyethoxy) vinylsilane was determined to be  >2000 mg/kg, indicating a very low order of toxicity in the rat by this route.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In an acute dermal toxicity study, conducted according to OECD 402 and in compliance with GLP, an LD50 value of >2000 mg/kg bw was determined for rats.