Tris(2-methoxyethoxy)vinylsilane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

3 March 1999 - 21 June 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Tris(2-methoxyethoxy)vinylsilane

EC Number:

213-934-0

EC Name:

Tris(2-methoxyethoxy)vinylsilane

Cas Number:

1067-53-4

Molecular formula:

C11H24O6Si

IUPAC Name:

ethenyl-tris(2-methoxyethoxy)silane

Test animals

Species:

rat

Strain:

other: Crl:CD(SD)IGS BR

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles river Laboratories, Raleigh, NC
- Age at study initiation: 10-11 weeks (males), 11-12 weeks (females)
- Weight at study initiation: 274-353 grams (males), 212-262 grams (females) at initiation of dosing
- Housing: individually suspended wire-mesh cages.
- Diet: PMI Nutrition International, Inc. Certified Rodent LabDiet 5002, ad libitum
- Water: reverse osmosis treated municipal water, ad libitum
- Acclimation period: minimum of 7 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22.1-22.3
- Humidity (%): 45-56
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

No data available.

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5 males and 5 females

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

- Frequency of observations and weighing: The test animals were observed for overt signs of toxicity at 1, 3, and 4 hours, and once daily thereafter for 14 days. Animals were observed twice daily for mortality. Body weights were recorded on Days 0, 7, and 14.

- Necropsy of survivors performed: yes

- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Examination of the cranial, thoracic and abdominal cavities was carried out after sacrificing the animals.

Statistics:

No data available.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

One male and one female died during the first week of dosing.

Clinical signs:

other: A majority of the rats were noted with various discoloured areas due to discharges/excretions. Other findings in approximately one-third of the animals included abnormal excretion, hypoactivity and tremors.

Gross pathology:

Gastrointestinal abnormalities were noted for one animal that died.

Other findings:

No other findings reported.

Any other information on results incl. tables

Based on these results, the acute oral LD50 of A-172 was determined to be greater than 2000 mg/kg, indicating a very low order of toxicity in the rat by this route.

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Remarks:

Not classified according to Regulation (EC) No. 1272/2008.

Conclusions:

In an acute oral toxicity study, conducted according to an appropriate test protocol and in compliance with GLP, an LD50 value of >2000 mg/kg bw for rats was determined.