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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation is likely to be minimal based upon secondary published data on humans and a reviewed study (Imoto et al., 1986) in which effects on rabbit skin were observed.  Eye irritation is likely to be transient and reversible based upon brief irritation observed in rabbits (Cerven, 1985).  No reports of respiratory irritation in animals or humans are available in the secondary sources that have reported on effects due to inhalation exposure to EGDN.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

SKIN IRRITATION/CORROSION: Clayton & Clayton (1982) reports that no animal tests for skin effects have been reported, but that "extensive human experience indicates that ethylene glycol dinitrate is not likely to give rise to skin irritation". A chronic dermal study in rabbits (Imoto et al.1986) reported erythema, edema, papules, scales, and skin thickening at all dose levels tested (15, 60 and 240 mg/kg). All dermal irritation effects were reversible upon cessation of exposure.

EYE IRRITATION: In a study (Cerven 1985) in which rabbit eyes were administered NG (read-across), conjuctival effects were observed only at one hour post-exposure with no miosis, mydriasis, other ocular effects, or systemic effects observed at any observation time for the next seven days. All rabbit eyes were normal following the one hour time point.

RESPIRATORY IRRITATION: From several secondary sources, respiratory irritation was not reported in animals or humans following inhalation exposure to EGDN.

Effects on skin irritation/corrosion: slightly irritating

Justification for classification or non-classification