Registration Dossier
Registration Dossier
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EC number: 211-063-0 | CAS number: 628-96-6
Endpoint summary
Administrative data
Description of key information
Skin irritation is likely to be minimal based upon secondary published data on humans and a reviewed study (Imoto et al., 1986) in which effects on rabbit skin were observed. Eye irritation is likely to be transient and reversible based upon brief irritation observed in rabbits (Cerven, 1985). No reports of respiratory irritation in animals or humans are available in the secondary sources that have reported on effects due to inhalation exposure to EGDN.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
SKIN IRRITATION/CORROSION: Clayton & Clayton (1982) reports that no animal tests for skin effects have been reported, but that "extensive human experience indicates that ethylene glycol dinitrate is not likely to give rise to skin irritation". A chronic dermal study in rabbits (Imoto et al.1986) reported erythema, edema, papules, scales, and skin thickening at all dose levels tested (15, 60 and 240 mg/kg). All dermal irritation effects were reversible upon cessation of exposure.
EYE IRRITATION: In a study (Cerven 1985) in which rabbit eyes were administered NG (read-across), conjuctival effects were observed only at one hour post-exposure with no miosis, mydriasis, other ocular effects, or systemic effects observed at any observation time for the next seven days. All rabbit eyes were normal following the one hour time point.
RESPIRATORY IRRITATION: From several secondary sources, respiratory irritation was not reported in animals or humans following inhalation exposure to EGDN.
Effects on skin irritation/corrosion: slightly irritating
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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