Ethylene dinitrate

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.003 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

0.019 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0 mg/L

Assessment factor:

100

Extrapolation method:

assessment factor

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

1.3 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

0.004 mg/kg sediment dw

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

0 mg/kg sediment dw

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

0.003 mg/kg soil dw

Extrapolation method:

equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

no potential for bioaccumulation

Additional information

The sediment-water partition coefficient used for equilibrium partitioning was derived for EGDN using the equations and guidance provided in chapter 16 of the REACH guidance document (Table 4)

Table 4: Derivation of the sediment-water partition coefficient for EGDN

Symbol	Parameter	Value	Unit	Reference
Focsusp	weight fraction solids in sediment	0.1	kg/kg	from Table R.16-9
Koc	organic carbon-water partition coefficient	24.9	L/kg	median of two QSAR estimates from EPIWEB
Kpsusp	solid-water partition coefficient in sediment	2.49	L/kg	Calculated using equation R.16-6^1
Fwatersusp	fraction of water in the sediment compartment	0.9	m^3/m^3	from Table R.16-9 (m3/m3)
Fsolidsusp	fraction of solids in the sediment compartment	0.1	m^3/m^3	from Table R.16-9 (m3/m3)
RHOsolid	density of solid phase	2500	kg/m3	from Table R.16-9 (kg/m3)
Ksusp-water	sediment-water partition coefficient	1.52	m^3/m^3	Calculated using Equation R.16-7 from REACH guidance^2

1-    Equation R.16-6: Kp_susp= Koc x Foc_susp

2-    Equation R-16-7: K_susp-water= (Fair_suspx K_air-water)+ Fwater_susp+ (Fsolid_suspx Kp_susp/1000 x RHOsolid)

Table 5 summarizes the PNEC derivation, including all input parameters used in the equations. Derivation of the sediment-water partition coefficient is summarized in Table 4. The resulting PNECs were estimated as 0.004 mg/kg ww for freshwater sediment, and 0.0004 mg/kg ww for marine sediment.

Table 5: Derivation of PNECs for freshwater and marine sediment

Symbol	Parameter	Value	Unit	Reference
PNECwater	Predicted No Effect Concentration in freshwater	0.003	mg/L	See derivation in Table 2.
PNECsaltwater	Predicted No Effect Concentration in marine water	0.0003	mg/L	See derivation in Table 2.
RHOsusp	bulk density of suspended matter	1150	kg/m^3	Value from equation R.10-2 from REACH guidance document
Ksusp-water	sediment-water partition coefficient	1.52	--	Equation R.16-7 (see derivation in Table 1)
PNEC freshwater sediment	Predicted No Effect Concentration in freshwater sediment	0.0040	mg/kg ww	Equation R.10-2 from REACH guidance document
PNEC marine sediment	Predicted No Effect Concentration in marine sediment	0.0004	mg/kg ww	Equation R.10-3 from REACH guidance document

ww = wet weight concentration

1.    Equation 10-2: PNECsed = (K_susp-water/ RHOsusp) x PNECwater x 1000

2.    Equation 10-3: PNECmarine-sediment = (K_susp-water/ RHOsusp) x PNECwater x 1000

The soil-water partition coefficient used for equilibrium partitioning was derived for EGDN using the equations and guidance provided in chapter 16 of the REACH guidance document (Table 6)   

 

Table 6: Derivation of the soil-water partition coefficient for EGDN

Symbol	Parameter	Value	Unit	Reference
Focsoil	weight fraction of organic carbon in soil	0.02	kg/kg	from Table R.16-9 in REACH guidance document
Koc	organic carbon-water partition coefficient	24.9	L/kg	median of two QSAR estimates from EPIWEB
Kpsoil	solid-water partition coefficient in soil	0.498	L/kg	Calculated using equation R.16-6^1
H	Henry's law constant	0.281	Pa-m^3/mol	value based on VP/Wsol from EPIWEB
R	gas constant	8.314	Pa-m^3/mol-K
Temp	temperature	285	K	K (from Eqn R16-5)
Kair-water	air water partitioning coefficient	0.000119	--	Equation R.16-5 from REACH guidance
Fwatersoil	fraction of water in soil compartment	0.2	m3/m3	from Table R.16-9 (m3/m3)
Fsolidsoil	fraction of solids in soil compartment	0.6	m3/m3	from Table R.16-9 (m3/m3)
RHOsolid	density of the solid phase	2500	m3/m3	from Table R.16-9 (kg/m3)
Fairsoil	fraction of air in soil compartment	0.2	m3/m3	from Table R.16-9 (m3/m3)
Ksoil-water	soil-water partition coefficient	0.947	m3/m3	Equation R.16-7

1-    Equation R.16-6: Kp_soil= Koc x Foc_soil

2-    Equation R.16-5: K_air-water= H / (R x Temp)

3-    Equation R.16-7: K_soil-water= (Fair_soilx K_air-water)+ Fwater_soil+ (Fsolid_soilx Kp_soil/1000 x RHOsolid)

 

The approach for deriving soil PNECs using this method is outlined in Chapters 10 and 16 of the REACH guidance document.  Table 6 summarizes the derivation, which resulted in an estimated soil PNEC of 0.0025 mg/kg ww.

Table7: Derivation of PNEC for soil

Parameter	Description	Value	Unit	Reference
PNEC water	Predicted No Effect Concentration in water	0.003	mg/L	See Table 2.
RHOsoil	bulk density of wet soil	1150	kg/m^3	Value from equation R.10-5 from REACH guidance document
Ksoil-water	soil-water partition coefficient	0.947	--	Equation R.16-7; see Table 6
PNEC soil	Predicted No Effect Concentration in wet soil	0.0025	mg/kg ww	Equation R.10-5 from REACH guidance document

ww = wet weight concentration

1.    Equation 10-5: PNECsoil = (K_soil-water/ RHOsoil) x PNECwater x 1000