Ethylene dinitrate

Endpoint summary

Description of key information

Three acute oral toxicity studies and one acute dermal toxicity study were available from which to select the effect levels below. No acute inhalation studies were available. However, acute exposure modeling indicated that the acute air concentration was below the DNEL for long-term exposure. Given that the long-term DNEL would be protective of both long-term and acute effects, derivation of a separate DNEL for acute exposure was not considered necessary.  The value provided as the inhalation LC50 below is equivalent to the long-term inhalation DNEL.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

460 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Dose descriptor:

LC50

Value:

0.085 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

3 800 mg/kg bw