Registration Dossier
Registration Dossier
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EC number: 211-063-0 | CAS number: 628-96-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 3.04 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 15 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rabbit
Additional information
ORAL: The NOAEL for chronic oral toxicity is based upon Study #004 (Ellis et al. 1984) for the two-year rat feeding study. This was used as the point-of-departure for the long-term oral DNEL (and the long-term inhalation DNEL, see below).
DERMAL: The LOAEL for local dermal effects is based upon Imoto et al. (1986). This study also identified a systemic NOAEL of 60 mg/kg-day for decreased neutrophil counts and increased heart and kidney weights.
INHALATION: There were no chronic inhalation studies from which to establish an effect level. For the derivation of the long-term inhalation DNELs, the chronic oral study (Ellis et al. 1984) was used as a point-of-departure.
Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: hematopoiesis; glandular: mammary gland
Repeated dose toxicity: dermal - systemic effects (target organ) other: skin
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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