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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited data given in the study report.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The study was performed before the adoption of any Guideline for eye irritation testing.The albino rabbit was used. The product was applied to the right eye of the animals, and the left was used as a control. Observations were made 24, 48 and 72 hours post-instillation. Irritation was scored according to Draize's scale. No data is given on the duration of exposure and the observation period.

GLP compliance:
no
Remarks:
The study was performed before the adoption of GLP.

Test material

Constituent 1
Reference substance name:
Benzenesulfonic acid, dodecyl-, branched, compd. with 2-propanamine
EC Number:
290-709-3
EC Name:
Benzenesulfonic acid, dodecyl-, branched, compd. with 2-propanamine
Cas Number:
90218-35-2
IUPAC Name:
90218-35-2
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): Witconate P1059 (data on the test material presented below were collected from an MSDS for a product under the same trade name found in the internet)
- Substance type: product
- Physical state: liquid
- Analytical purity: 90%
- Appearance: (25°C) Clear amber liquid at 25 C max
- Gardner: 0 - 7
- Moisture 4.0 - 5.0 %
- pH 20% in 25% IPA 4.5 - 5.5

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal: 1, 2, 3, 4, 5, 6 (individually)
Time point:
other: 24, 48, 72 h
Score:
1
Max. score:
1
Reversibility:
not specified
Irritation parameter:
iris score
Basis:
animal: 1, 2, 3, 4, 5, 6 (individually)
Time point:
other: 24, 48, 72 h
Score:
0
Irritation parameter:
conjunctivae score
Basis:
animal: 1, 2, 3, 4, 5 (individually)
Time point:
other: 24, 48, 72 h
Score:
2.6
Max. score:
3
Reversibility:
not specified
Irritation parameter:
conjunctivae score
Basis:
animal #6
Time point:
other: 24, 48, 72 h
Score:
2
Max. score:
2
Reversibility:
not specified
Irritation parameter:
chemosis score
Basis:
animal: 1, 2, 3, 4 (individually)
Time point:
other: 24, 48, 72 h
Score:
0.3
Max. score:
1
Reversibility:
not specified
Irritation parameter:
chemosis score
Basis:
animal #5
Time point:
other: 24, 48, 72 h
Score:
1.3
Max. score:
2
Reversibility:
not specified
Irritation parameter:
chemosis score
Basis:
animal #6
Time point:
other: 24, 48, 72 h
Score:
0
Other effects:
No other effects described.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of this test Witconate P1059 (Benzenesulfonic acid, dodecyl-, branched, compd. with 2-propanamine) is irritating to the eye of the rabbit.
Executive summary:

The eye irritation potential of Witconate P1059 (Benzenesulfonic acid, dodecyl-, branched, compd. with 2-propanamine, CAS No 90218-35-2) was tested on six rabbits. The test material (0.1 ml) was instilled into the right eye of each animal, while the left eye was used a s a control. Examination was made at 24, 48 and 72 hours. Irritation was scored according to the Draize scale. No data are provided on the observation period, i.e. no conclusion can be drawn on the reversibility of the effect. Most of the animals showed a positive response (≥1) in at least one of the measured endpoints. Based on this result Witconate P1059 is irritating to the eye (Eye Irrit. 2, H319: Causes serious eye irritation) of the rabbit.