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Partition coefficient

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Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Remarks:
estimated by calculation
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
calculation method not given
Principles of method if other than guideline:
Calculated
GLP compliance:
not specified
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.15
Remarks on result:
other: no information on temperature and pH
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference in Japanese, not translated
Principles of method if other than guideline:
not provided
GLP compliance:
not specified
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.11
Remarks on result:
other: no information on temperature and pH
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
Measured phase partitioning after phase saturation
GLP compliance:
not specified
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
ca. 1.47
Temp.:
25 °C
pH:
6.9
Endpoint:
partition coefficient
Type of information:
other: no data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
secondary peer reviewed source, valid collection of data
GLP compliance:
not specified
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.15
Remarks on result:
other: the pH value and the temperature were not reported
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Principles of method if other than guideline:
According to OECD Chemicals Testing Programme Ecotoxicology Group, 1979
GLP compliance:
no
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
0.55
Temp.:
25 °C
Remarks on result:
other: the pH value was not reported
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
counter current chromatography
GLP compliance:
no
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.04
Remarks on result:
other: no information on temperature and pH
Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
KOWWIN v.1.67
Principles of method if other than guideline:
Calculated with KOWWIN v.1.67, 2000
GLP compliance:
no
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.3
Temp.:
25 °C
Remarks on result:
other: the pH value was not reported

The pH-value was not reported, because it is a calculated method.

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
guideline not specified
GLP compliance:
no
Type of method:
other: not specified
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
1.15
Remarks on result:
other: Temperature and pH not reported

This value is designated as the preferred value measured as or converted to the neutral form.

The temperature is not reported.

Executive summary:

Hansch C, 1995

The measured logPow of phthalimide is 1.15.

Description of key information

The available references report consistent values in the range between 1,03-1,47, with the value of 1,15 being the most frequently reported.


One reference reports a value of 0,55, which, although deviating,remains comparable to the key value.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.15

Additional information