Phthalimide

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

results derived from a (Q)SAR model, with limited documentation / justification

Justification for type of information:

QSAR prediction - not commonly used calculation method in the time of the calculation.

Principles of method if other than guideline:

method not given

GLP compliance:

no

Water solubility:

586 mg/L

Temp.:

25 °C

Remarks on result:

other: pH value not given

result: log(1/S)=2.40; S=molar water solubility (mol/l)

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

not specified

Water solubility:

< 1 g/L

Temp.:

19.5 °C

Remarks on result:

other: The pH-value is not reported.

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

not specified

GLP compliance:

not specified

Water solubility:

ca. 0.6 g/L

pH:

ca. 3.8

Remarks on result:

other: The temperature was not reported.

Reference 4

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

method not specified

GLP compliance:

not specified

Water solubility:

36 mg/L

Temp.:

25 °C

Remarks on result:

other: The pH-value is not reported.

Reference 5

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study according to Japanese national guideline. Original report in Japanese.

Principles of method if other than guideline:

Method: Japanese national guideline (1988)

GLP compliance:

not specified

Water solubility:

370 mg/L

Temp.:

25 °C

Remarks on result:

other: The pH-value is not reported.

Reference 6

Endpoint:

water solubility

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

WSKOW v. 1.41

Principles of method if other than guideline:

Calculated with (WSKOW v. 1.41)

GLP compliance:

no

Water solubility:

216 mg/L

Temp.:

25 °C

Remarks on result:

other: pH not reported

The EPIWIN Program (EPA, 2004) used for calculation also cites a water  solubility of 360 mg/l in the SRC PhysProp Database as experimental data  of Yalkowsky and Dannenfelser (1992)

Reference 7

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

method not specified

GLP compliance:

not specified

Key result

Water solubility:

360 mg/L

Remarks on result:

other: The pH-value and the temperature were not reported. The value is assumed to be measured at 25 °C

The pH-value and the temperature were not reported. The value is assumed to be measured at 25 °C

Executive summary:

HSDB, 2009

Aqueous solubility of phthalimide: 360 mg/l.

The temperature is not reported. The value is assumed to be measured at 25 °C.

Description of key information

Available sources give consistent values between 200 and 600 mg/L. 

Key value for chemical safety assessment

Water solubility:

360 mg/L

at the temperature of:

25 °C

Additional information

Although a certain discrepancy is observed in the values from different sources, the available data is sufficient to decide on a value to be considered as key. 

One aberrrant value is possibly explained by inaccurate reporting.