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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is not available and has not been reviewed.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Phthalimide - CAS No: 85-41-6
Author:
OECD SIDS
Year:
2005
Bibliographic source:
SIDS Initial Assessment Report for 20th SIAM, UNEP Publications 2005
Reference Type:
other company data
Title:
Unnamed
Year:
1974

Materials and methods

Principles of method if other than guideline:
One male animal (2.4 kg) was dosed with 5010 mg/kg bw and two animals (one male, 2.2 kg, and one female, 2.2 kg) were dosed with 7940 mg/kg bw for 24 hours, and observed for 14 days
GLP compliance:
no
Remarks:
GLP was not mandatory at the time of the study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Analytical purity: not indicated

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Vehicle:
other: 40% solution-suspension in corn oil
Duration of exposure:
24 hours
Doses:
5010 and 7940 mg/kg bw
No. of animals per sex per dose:
1
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Remarks on result:
other: rabbit
Mortality:
No mortality was observed
Clinical signs:
Animals showed reduced appetite and activity for one to two days
Gross pathology:
The viscera appeared normal at end of experiment (14 days)

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU