Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
MIGRATED DATASET. Methodological deficiencies. During exposure period sample changed from fine, white powder to light tan crystalline solid. No analytics on exposure concentration. Adopted according to OECD SIDS (public available peer reviewed source). The original source is not available and has not been reviewed.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Phthalimide - CAS No: 85-41-6
Author:
OECD SIDS
Year:
2005
Bibliographic source:
SIDS Initial Assessment Report for 20th SIAM, UNEP Publications
Reference Type:
other company data
Title:
Unnamed
Year:
1970

Materials and methods

Principles of method if other than guideline:
Migrated dataset
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Migrated dataset. IUCLID4 Test substance: other TS: phthalimide heated to 150 degree Celsius

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Duration of exposure:
6 h
No. of animals per sex per dose:
6

Results and discussion

Effect levels
Dose descriptor:
other: migrated dataset
Remarks on result:
other: migrated dataset

Any other information on results incl. tables

Amount of vaporized phthalimide: 0.0 g(amount of sample at start and end: 56.2 g). 
During exposure period sample changed from fine, white  powder to light tan 
crystalline solid.

Animal no./sex fate observations during exposure
1 /male survived no immediate effect
2 /male survived normal reaction
3 /male survived no discharge
4 /male survived no weaknes
5 /male survived
6 /male survived

All animals survived the ten days observation period; the vapors were practically non-toxic.
The ten days observation period was uneventful. The viscera appeared normal by microscopic examination.

Applicant's summary and conclusion