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Physical & Chemical properties

Dissociation constant

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Description of key information

Ethanol:
logpKa=15.76 by QSAR
logpKa=15.9 from a secondary source
Isopropanol:
In accordance with section 1 of REACH Annex XI, the dissociation constant study (required in section 7.16) does not need to be conducted as inspection of the chemical structure shows no functional groups which are associated with dissociation behaviour at relevant environmental conditions.

Key value for chemical safety assessment

Additional information

Based on data from the two constituents it can be concluded that dissociation is not a significant property of the reaction mass under any conceivable environmental or biological conditions. This confirms expert assessment that indicates no dissociable groups within the molecule.

Ethanol:

Information from a QSAR model and a reliable secondary source are sufficiently consistent to conclude that dissociation is not a significant property of this substance under any conceivable environmental or biological conditions. This confirms expert assessment that indicates no dissociable groups within the molecule.

Isopropanol

The pKa of IPA was calculated using the ACD/I-Lab service ACD/LogP v8.02, and was reported as 15.31 ± 0.20. The substance will therefore predominantly exist in the undissociated form throughout the environmentally relevant pH range of 5 to 9. The information on the temperature was not reported.