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EC number: 902-053-3 | CAS number: -
The amount penetrating was greater in the occluded than the unoccluded cells. The maximum flux rate was reached within 1 hour.
Note that if the total penetrating (in mg/cm2) is corrected for the recovered quantitities, the total penetrating would become 5.5 and 4.5mg/cm2 respectively, which suggests that occlusion state does not affect actual penetration rate significantly and that the total penetration is actually dependent on whether evaporation occurs or not..
In a study to assess the skin penetration potential of ethanol, an in vitro study was carried out using excised pig skin and radiolabelled ethanol. Ethanol penetration was greater under occlusion conditions than non-occlusive conditions, as might be expected. Absorption rates were around 21% and 1% of applied doses respectively.
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