Registration Dossier
Registration Dossier
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EC number: 902-053-3 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Interspecies Comparisons of Skin Irritancy
- Author:
- Nixon G, Tyson C & Wertz W
- Year:
- 1 975
- Bibliographic source:
- Toxicology and Applied Pharmacology 31, 481-490 (1975)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- This test followed the revised Federal Hazardous Substances Act (FHSA) procedure that had been proposed by the FDA (Edwards, 1972), with a 4-hour rather than 24-hour exposure.
- GLP compliance:
- no
Test material
- Reference substance name:
- Propan-2-ol
- EC Number:
- 200-661-7
- EC Name:
- Propan-2-ol
- Cas Number:
- 67-63-0
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Isopropyl alcohol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No details provided.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No details provided.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- at 4, 24, and 48 hours
- Number of animals:
- No details provided.
- Details on study design:
- TEST SITE
- Area of exposure: 2 intact sites and 2 abraded sites per animal
- % coverage: not reported
- Type of wrap if used: patch (unspecified)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not reported
- Time after start of exposure: not reported
SCORING SYSTEM: see below
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4, 24, 48 hr
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: no irritation observed
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 4, 24, 48 hr
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: no irritation observed
- Irritation parameter:
- other: tissue destruction
- Basis:
- mean
- Time point:
- other: 4, 24, 48 hr
- Score:
- 0
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- other: no corrosion observed in any (0) of the 6 sites tested
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: other: CLP (EC 1278/2008)
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