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Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: QSAR regarded as reliable.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR model
Title:
Ecological Structure Activity Relationships (ECOSAR) model) v1.00a
Author:
US EPA
Year:
2009
Bibliographic source:
http://www.epa.gov/oppt/newchems/tools/21ecosar.htm

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
QSAR model

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test organisms

Test organisms (species):
no data

Study design

Test type:
not specified
Water media type:
freshwater
Total exposure duration:
30 d

Results and discussion

Effect concentrations
Duration:
30 d
Dose descriptor:
other: ChV (equivalent to a NOEC)
Effect conc.:
245 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality

Any other information on results incl. tables

This result compares to the prediction from the model that the chronic toxicity threshold value for daphnid is 92mg/l and that for green algae 56mg/l. This is also consistent with the acute toxicity results predicted by the model of 2178mg/l (96hr, fish), 1117mg/l (48hr daphnid), 209mg/l (96hr algae). The acute toxicity data is highly consistent with the measured data and this gives confidence to the conclusion that fish are not likely to be the most sensitive species in a chronic toxicity study.

Applicant's summary and conclusion