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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data have been obtained from secondary source.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Toxicological Profile for dinitrophenol
Author:
M. Olivia Harris, M.A; James J. Corcoran, Ph.D. (peer rewied by Dr. martin Alexander; Dr.Leon Koller; Dr.Norman Trieff)
Year:
1995
Bibliographic source:
U.S Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry
Reference Type:
review article or handbook
Title:
Mutagenicity of some commercially available nitro compounds
Author:
Chiu CW, Lee LH, Wang CY, et al.
Year:
1978
Bibliographic source:
Mutat Res 58:l l-22

Materials and methods

Principles of method if other than guideline:
Method included an in vitro test, without metabolic activation by rat liver S9 microsomes on Salmonella Thyphimurum. Details on method have not been specified.
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Species / strain
Species / strain / cell type:
other: TA98, TA100
Metabolic activation:
without
Metabolic activation system:
rat liver S9 microsomes

Results and discussion

Test results
Species / strain:
other: TA98, TA100
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative without metabolic activation

In vitro study for reverse mutation on Salmonella Thypimurium, strain TA98, TA100, without rat liver S9 metabolic activation is negative.
Executive summary:

Data have been obtaioned from a secondary source, that mentions Chiu CW, Lee LH, Wang CY, et al. 1978. Mutagenicity of some commercially available nitro compounds. Mutat Res 58:l l-22. An in vitro study of reverse mutation on procariotic organism Salmonella Thypimurium, strain TA98, TA100 was performed without rat liver S9 microsomes metabolic activation.

The results show that 2,4 -dinitrophenol is negative for reverse mutation test.