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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data have been obtained from secondary source.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Toxicological Profile for dinitrophenol
Author:
M. Olivia Harris, M.A; James J. Corcoran, Ph.D. (peer rewied by Dr. martin Alexander; Dr.Leon Koller; Dr.Norman Trieff)
Year:
1995
Bibliographic source:
U.S Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry
Reference Type:
review article or handbook
Title:
Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture.
Author:
Spencer HC, Rowe VK, Irish DD.
Year:
1948
Bibliographic source:
J Ind Hyg Toxicol 30:10-25, 1948

Materials and methods

Principles of method if other than guideline:
Application by bandage on abdomen. Further details of the test have not been specified.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: solution
Details on test material:
Composition of test material, percentage of components: solution of 3% of 2,4-dinitrophenol and 95% ethanol.

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
other: bandage
Preparation of test site:
shaved

Results and discussion

Any other information on results incl. tables

The result of the test indicates a very slight irritation, including mild hyperemia, edema and exfoliation.

Applicant's summary and conclusion

Interpretation of results:
other: very slight irritation
Remarks:
Criteria used for interpretation of results: other: criteria used to assess not reported.
Conclusions:
2,4-dinitrophenol is very slight irritant.
Executive summary:

All information has been obtained from secondary source, that mentions Spencer HC, Rowe VK, Irish DD. 1948. Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture. J Ind Hyg Toxicol 30:10-25.

Solution of 3% of 2,4-dinitrophenol and 95% ethanol was applied through a bandage on rabbit shaved abdomen.

The result indicates that 2,4-dinitrophenol is a very slight irritant, including effects of mild hyperemia, edema and exfoliation, but in the study criteria of assessment it hasn't been reported.