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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data has been obtained from secondary source.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Toxicological Profile for dinitrophenol
Author:
M. Olivia Harris, M.A; James J. Corcoran, Ph.D. (peer rewied by Dr. martin Alexander; Dr.Leon Koller; Dr.Norman Trieff)
Year:
1995
Bibliographic source:
U.S Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry
Reference Type:
study report
Title:
Unnamed
Year:
1964

Materials and methods

Principles of method if other than guideline:
Method has not been specified. The study is considered reasonably well conducted.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
4 weeks

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
59 mg/kg diet
Sex:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

No mortality LD0 was observed at dose <= 59 mg/Kg/day. A NOAEL of 59 mg/kg/day was determinated because food consumption and body weight gain in rats exposed to that dose of 2,4 -dinitrophenol in the diet for 4 weeks were similar to those of controls.

Applicant's summary and conclusion

Conclusions:
LD0 was observed at dose <= 59 mg/Kg/day.
A NOAEL of 59 mg/kg/day was observed for food consumption and body weight gain.
Executive summary:

Data has been obtained from secondary source that mentions Kaiser JA. 1964. Studies on the toxicity of diisophenol (2,6-diiodo-4-nitrophenol) to dogs and rodents plus some comparison with 2,4-dinitrophenol. Toxicol Appl Pharmacol 6:232-244.

Weanling rats were exposed to 2,4 -dinitrophenol in the feed for 4 weeks. No mortality LD0 was observed at dose <= 59 mg/Kg/day. A NOAEL of 59 mg/kg/day was determined because food consumption and body weight gain in rats exposed to that dose of 2,4 -dinitrophenol in the diet for 4 weeks were similar to those of controls.

Method has not been specified but the study is considered reasonably well conducted.