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Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data have been obtained from secondary source.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Toxicological Profile for dinitrophenol
Author:
M. Olivia Harris, M.A; James J. Corcoran, Ph.D. (peer rewied by Dr. Martin Alexander; Dr.Leon Koller; Dr.Norman Trieff)
Year:
1995
Bibliographic source:
U.S Department of Health and human Services, Public Health Service Agency for Toxic Substances and Disease Registry
Reference Type:
review article or handbook
Title:
Studies on photochemical reaction of air pollutants: X. Identification of nitrophenols in suspended particulates.
Author:
Nojima K, Kawaguchi A, Ohya T, et al.
Year:
1983
Bibliographic source:
Chem Pharm Bull 31: 1047-1051, 1983

Materials and methods

Principles of method if other than guideline:
Gas chromatographic (GC) and high-performance liquid chromatographic (HPLC) columns are often used as the final step towards resolution with a a variety of detectors to quantify dinitrophenols; The method consisted in the detection of both 2,4- and 2,6-DNP in particulate matter in air in Yokohama, Japan for 5 days.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

The reported concentration ranges of 2,4 -dinitrophenol in particulate matter in air in Yokohama, Japan, during 5 days were 2.4-12 μg/g particulates, that are indirect indications of the presence of these compounds in the air.

The observation that dinitrophenols are found at least partly in the particulate-sorbed state in the air indicates that their bioavailability from air is < 100%.

Applicant's summary and conclusion

Conclusions:
The reported concentration ranges of 2,4 -dinitrophenol in particulate matter in air in Yokohama, Japan, during 5 days were 2.4-12 μg/g particulates, that are indirect indications of the presence of these compounds in the air.
The observation that dinitrophenols are found at least partly in the particulate-sorbed state in the air indicates that their bioavailability from air is < 100%.

Executive summary:

Data have been obtained from secondary source that mentions Nojima K, Kawaguchi A, Ohya T, et al. 1983. Studies on photochemical reaction of air pollutants: X. Identification of nitrophenols in suspended particulates. Chem Pharm Bull 31: 1047-1051.

The method consisted in the detection of both 2,4- and 2,6-DNP was done by GC in particulate matter in air in Yokohama, Japan for 5 days.

Because underivatized nitrophenols are irreversibly sorbed on active sites of GC column materials, it may be necessary to derivatize the compounds to increase their volatility to enhance elution from the GC column.

The reported concentration ranges of 2,4 -dinitrophenol in particulate matter in air in Yokohama during the 5 days were 2.4-12 μg/g particulates, that are indirect indications of the presence of these compounds in the air.

The observation that dinitrophenols are found at least partly in the particulate-sorbed state in the air indicates that their bioavailability from air is < 100%.