Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data have been obtained from secoundary source.

Data source

Referenceopen allclose all

Reference Type:
other: databank
Title:
Unnamed
Year:
2012
Reference Type:
other: original reference
Title:
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure,"
Author:
Izmerov, N.F., et al.
Year:
1982
Bibliographic source:
85GMAT , Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,62, 1982

Materials and methods

Principles of method if other than guideline:
The method has not been specified.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
dog
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
30
Remarks on duration:
Months
Concentrations:
300 mg/m3

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LCLo
Effect level:
300 other: mg/m^3
Remarks on result:
other: Duration: 30 M (months)

Any other information on results incl. tables

The LCLo-Lowest published lethal concentration on dog of 2,4 -dinitrophenol is 300 mg/m3. Details of toxic effects have not been reported other than lethal dose value.

Applicant's summary and conclusion

Conclusions:
The LCLo-Lowest published lethal concentration on dog , tested in 30 Months of 2,4 -dinitrophenol is 300 mg/m^3. Details of toxic effects have not been reported other than lethal dose value.
Executive summary:

Data have been obtained from secoundary source taht mentions 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,62,1982. The method has not been specified. The LCLo-Lowest published lethal concentration on dog of 2,4 -dinitrophenol is 300 mg/m3 for 30 months but details of toxic effects have not been reported other than lethal dose value.