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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data have been obtained from secondary source.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Toxicological Profile for dinitrophenol
Author:
M. Olivia Harris, M.A; James J. Corcoran, Ph.D. (peer rewied by Dr. martin Alexander; Dr.Leon Koller; Dr.Norman Trieff)
Year:
1995
Bibliographic source:
U.S Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry
Reference Type:
review article or handbook
Title:
Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture.
Author:
Spencer HC, Rowe VK, Irish DD.
Year:
1948
Bibliographic source:
J Ind Hyg Toxicol 30:10-25, 1948

Materials and methods

Principles of method if other than guideline:
Guinea pigs were exposed dermally to 100-1,000 mg/kg 2,4-dinitrophenol for 4 hours.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Duration of exposure:
4 hours
Doses:
To 100-1000 mg/kg of 2,4-dinitrophenol

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD0
Effect level:
ca. 100 - 200 other: mg/kg
Sex:
not specified
Dose descriptor:
other: LD20
Effect level:
300 other: mg/kg
Sex:
not specified
Dose descriptor:
LD100
Effect level:
700 other: mg/kg
Sex:
not specified
Dose descriptor:
other: LOAEL
Effect level:
300 other: mg/kg

Any other information on results incl. tables

No mortality was observed at 100 -200 mg/kg.

The lowest dose causing mortality LD20 was 300 mg/kg (20 %)

The lowest dose causing totally the mortality LD100 was 700 mg/kg (100%).

Due to the local effect it might be possible to identify a LOAEL of 300 mg/kg.

Applicant's summary and conclusion

Conclusions:
No mortality was observed at 100 or 200 mg/kg. LD20 was 300 mg/kg (20% mortallity ), and the lowest dose causing 100% mortality was 700 mg/kg.
Due to the local effect it might be possible to identify a LOAEL of 300 mg/kg.
Executive summary:

Data have been obtained from secondary source tha mentions Spencer HC, Rowe VK, Irish DD. 1948. Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture. J Ind Hyg Toxicol 30:10-25.Guinea pigs were exposed dermally to 100-1,000 mg/kg 2,4-DNP for 4 hours. No mortality was observed at 100 or 200 mg/kg. The lowest dose causing mortality at 20% was 300 mg/kg, and the lowest dose causing 100% mortality was 700 mg/kg. Due to the local effect it might be possible to identify a LOAEL of 300 mg/kg.