Registration Dossier
Registration Dossier
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EC number: 202-852-0 | CAS number: 100-43-6
Endpoint summary
Administrative data
Description of key information
4VP is corrosive to the skin and assumed corrosive to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
An analogue of 4VP, 2VP, showed severe eye irritation with corneal damage. Furthermore, in the Guidance on the Application of the CLP Criteria, ECHA, April, 2011, Section 3.3, substances classified as skin corrosive Category 1, as 4VP is, are implicitly considered to cause serious damage to the eyes and there is no reason to proceed with classification for eye effects.
Justification for selection of skin irritation / corrosion endpoint:
Guideline study showing corrosion after a 1 hour exposure
Justification for selection of eye irritation endpoint:
An analogue of 4VP showed severe eye irritation with corneal damage. Also, in the Guidance on the Application of the CLP Criteria, April, 2011, Section 3.3, substances classified as skin corrosive Category 1, as 4VP is, are implicitly considered to cause serious damage to the eyes.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
4-Vinylpyridine is corrosive to the skin of rabbits after exposures of 1 hour. The substance is classified as a Category 1B corrosive as it causes corrosion when applied to skin for a time period of between 3 minutes and 1 hour. It is assumed to be damaging to the eye, according to testing in a close structural analogue, 2VP. Furthermore, according to ECHA's Guidance on Regulation EC No. 1272/2008, substances corrosive to the skin, as 4VP is, are considered to be corrosive to the eye. Because the mechanism of action of 4-vinylpyridine involves corrosivity, the compound is classified as H071, corrosive to the respiratory tract.
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