4-vinylpyridine

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: The case report is from exposure to a mixture of chemicals, only 7% of which is vinylpyridine. A strong association between cause and effect cannot be made.

Data source

Reference

Reference Type:

publication

Title:

Vinylpyridine: an unusual casue of a chemical burn

Author:

Stone CA and K Dunn

Year:

1996

Bibliographic source:

Burns 22:150-151.

Materials and methods

Study type:

other: case report

Endpoint addressed:

skin irritation / corrosion

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Report of one case of a burn to a chemical exposure. The chemical is part of a mixture from a container 12 years old; it is not specifically identified as 2-VP

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-vinylpyridine

EC Number:

202-879-8

EC Name:

2-vinylpyridine

Cas Number:

100-69-6

IUPAC Name:

2-vinylpyridine

Method

Type of population:

occupational

Results and discussion

Clinical signs:

His initial reaction was contact dermatitis. It suddenly worsened 5 days later, when he sought medical attention for left-sided deep calf pain.

Results of examinations:

Five days after a spill to the leg of a 12-year old mixture of chemicals, 7% of which was an unspecified isomer of vinylpyridine, the leg area displayed livid erythema and marked swelling of the lower legs. There was also increased local temperature and superficial paraesthesia. The affected area was well demarcated over the left foot. The appearance was consistent with a superficial partial thickness burn.

Outcome of incidence:

After 10 days of medical treatment, the erythema and dermal oedema was significantly improved, leaving areas of patchy skin discolouration.

Any other information on results incl. tables

The main constituent of the original chemical was subsequently identified by mass spectroscopy as 7% m/m vinylpyridine, although the isomeric and polymeric status were unknown.

Applicant's summary and conclusion

Conclusions:

This is a case report of a burn to the skin of a worker from a mixture of chemicals 12 years old. The identify of the main constituent was a vinylpyridine, although the isomeric identity was not established. Contact dermatitis progress into a deep tissue burn after 5 days. After another 10 days of medical treatment, the burn was significantly healed.