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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
other: handbook
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: as provided in a reliable textbook of toxicology. No information is given on methods used.

Data source

Reference
Reference Type:
secondary source
Title:
Heterocyclic and Miscellaneous Nitrogen Compounds
Author:
Trochimowitcz, Henry J.
Year:
1982
Bibliographic source:
Patty's Industrial Hygiene and Toxicology, 3rd Ed. New York, NY: John Wiley & Sons, pp. 3362

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: no information
Principles of method if other than guideline:
No information is presented in this handbook excerpt. It is most likely conducted using an accepted experimental protocol.
GLP compliance:
not specified
Test type:
other: Acute inhalation toxicity in rodents

Test material

Constituent 1
Chemical structure
Reference substance name:
4-vinylpyridine
EC Number:
202-852-0
EC Name:
4-vinylpyridine
Cas Number:
100-43-6
Molecular formula:
C7H7N
IUPAC Name:
4-ethenylpyridine
Details on test material:
No information

Test animals

Species:
rat
Details on test animals or test system and environmental conditions:
no information

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
No information
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
> 2 - <= 6 h
Remarks on duration:
Data is provided for 2, 4.5 and 6 h duration periods
Concentrations:
150, 1000 and 2000 ppm
No. of animals per sex per dose:
No information
Details on study design:
No information

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC0
Effect level:
150 ppm
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: There were no deaths when rats were exposed to 150 ppm for 6 h.
Sex:
not specified
Dose descriptor:
LC0
Effect level:
1 000 ppm
Based on:
test mat.
Exp. duration:
4.5 h
Remarks on result:
other: There were no deaths when rats were exposed to 1000 ppm for 4.5 h.
Sex:
not specified
Dose descriptor:
LC100
Effect level:
2 000 ppm
Based on:
test mat.
Exp. duration:
2 h
Remarks on result:
other: All rats died by 2 h when they were exposed to 2000 ppm.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information The LC50 is between 1000 and 2000 ppm Criteria used for interpretation of results: EU
Conclusions:
The inhalatory LC50 of 4-Vinylpyridine in rats is estimated in this handbook excerpt to be greater than 1000 ppm and less than 2000 ppm.