Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Quality of whole database:
adequate
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information

The substance has been studied in a validated QSAR and found to be inactive for reproductive toxicity, or not a reproductive toxicant. When a structural analogue (2 -vinylpyridine) is studied in a 90-day repeated dose toxicity study, there is no evidence of toxicity to reproductive organs at doses causing systemic toxicity.


Short description of key information:
Review of the toxicity of reproductive organs in rats after subchronic exposure to a structural analogue, 2-vinylpyridine, the substance does not selectively target the reproductive organs. The substance is predicted by a validated QSAR to be inactive for reproductive toxicity, or "nonthreatening" to humans.

Justification for selection of Effect on fertility via oral route:
Valid QSAR model

Effects on developmental toxicity

Description of key information
A validated QSAR predicts 4-vinylpyridine to be "inactive" for developmental toxicity, or a "non developmental toxin".
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Quality of whole database:
adequate
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available
Additional information

Risk assessment for teratogenicity is performed qualitatively, based on a categorical structure-activity relationship (SAR). Using a validated SAR model of teratogenicity in humans based on 323 chemical substances, 4VP was predicted to be "inactive" or "not teratogenic".


Justification for selection of Effect on developmental toxicity: via oral route:
Validated (Q)SAR model

Justification for classification or non-classification

Existing in vivo studies of rats exposed to a structural analogue, 2-vinylpyridine, have been reviewed to ascertain the potential for reproductive toxicity. There is no evidence of toxicity to reproductive organs at doses causing systemic toxicity.

Concerning developmental toxicity, a structure-activity model predicts that 4-VP is inactive (not a developmental toxin, non-teratogenic).

Therefore, 4-VP is not considered to be a reproductive or developmental toxicant. Further testing is not appropriate, as this substance is corrosive at the site of contact. This is discouraged in Annex VIII and Annex IX introductions, where "in vivo testing with corrosive substances at concentration/dose levels causing corrosivity shall be avoided".

Additional information