Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
other: handbook
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Information is obtained from a reliable handbook of toxicology. No information is available on experimental method. As the substance is corrosive to the skin, likely causing pain and suffering to the animals, the introduction to Annex VIII of Regulation EC No. 1907/2006 advises against repeating the study in vertebrate animals.

Data source

Reference
Reference Type:
secondary source
Title:
Heterocyclic and Miscellaneous Nitrogen Compounds
Author:
Trochimowitcz, Henry J.
Year:
1982
Bibliographic source:
Patty's Industrial Hygiene and Toxicology, 3rd Ed. New York, NY: John Wiley & Sons, pp. 3362

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: no information
Principles of method if other than guideline:
No information is provided on the method used. Handling experience with this material has not resulted in the questioning of its accuracy.
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-vinylpyridine
EC Number:
202-852-0
EC Name:
4-vinylpyridine
Cas Number:
100-43-6
Molecular formula:
C7H7N
IUPAC Name:
4-ethenylpyridine

Test animals

Species:
guinea pig
Details on test animals or test system and environmental conditions:
no information

Administration / exposure

Type of coverage:
not specified
Details on dermal exposure:
No information
Duration of exposure:
No information
Doses:
no information other than the LD50 is less than 500 mg/kg.
No. of animals per sex per dose:
no information
Details on study design:
No information

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
500 mg/kg bw
Based on:
test mat.
Remarks on result:
other: The LD50 is less than 500 mg/kg bw in guinea pigs.

Any other information on results incl. tables

The guinea pig is not dissimilar to the rat for acute dermal toxicity testing. Standard protocols indicate that 10% of the body area is exposed to the test material. The allometric scaling factor for the guinea pig is similar to that of the rat, 3 and 4, respectively (Table R.8 -3 in Chapter R.8, Characteristics of dose (concentration)-response for human health, in Guidance for Information requirements and the chemical safety report, ECHA, Version 2, December 2010. Acute toxicity testing in the guinea pig is a fair estimate of the acute dermal toxicity in the rat.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information The LD50 is less than 500 mg/kg bw, falling within the upper limit of Category 3 Criteria used for interpretation of results: EU
Conclusions:
The LD50 of 4-vinylpyridine in guinea pigs was less than 500 mg/kg bw. This is a fair estimate of the acute dermal toxicity in the rat. As this substnace is corrosive to the skin, likely causing pain and suffering to the animals, it is inappropriate to repeat the study in vertebrate animals. Appropriate risk management measures will be recommended for use of this substance.