Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 December 2015 to 22 March 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP, HPLC method is less suitable for the surface active substance
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: cyanopropyl stationary phase
- Radiolabelling:
- no
- Test temperature:
- 30°C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Alliance Separation Module 2695 (Waters, Milford, MA, USA)
- Detector: Refractive index detector 2414 (Waters)
- Column: Hypersil BDS-CN, 150 mm x 4.6 mm i.d., dp = 5 µm (Thermo Fisher Scientific, Waltham, MA, USA)
- Column temperature: 35°C ± 1°C
- Mobile phase: 40/60 (v/v) methanol/water
- Flow: 1 mL/min
- Injection volume: 10 µL
- RI detection
Sensitivity 4
Time constant 1 second
Temperature 30°C
- pH: 7
- Solutes for dissolving test and reference substances: methanol/water 40/60
DETERMINATION OF DEAD TIME: no data
REFERENCE SUBSTANCE: Acetanilide
REPETITIONS: 2 for tes substance, reference substance and blanks
EVALUATION: comparison with retention time referebce substance - Key result
- Type:
- Koc
- Value:
- < 18
- Temp.:
- 30 °C
- Key result
- Type:
- log Koc
- Value:
- < 1.26
- Temp.:
- 30 °C
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: 2.415 and 2.420 min
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The logKoc of the substance is <1.26
- Executive summary:
Using the HPLC method the logKoc of the substance was determined to be <1.26.
Reference
Kocof the test item
Substance |
tr,1 |
tr,2 |
mean tr |
log Koc |
Koc |
Acetanilide |
2.415 |
2.420 |
|
1.26 |
|
Test item |
1.475 |
1.474 |
1.475 |
< 1.26 |
<18 |
Description of key information
Using the HPLC method the logKoc of the substance was determined to be <1.26.
Key value for chemical safety assessment
- Koc at 20 °C:
- 18
Additional information
The log Koc calculation in the BASF study is not further taken into account, as a study on the actual test substance is available.
[LogKoc: 1.26]
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