Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 907-672-2
CAS number: -
Nurturing or maternal behaviour did not appear to be the salient factor
in pup growth and survival. During the cross-fostering phase, careful
examination of the pups was made for the presence or absence of milk in
the stomach of the pups during the early days of lactation. The majority
of pups appeared to be nursing. The dams did not display abnormal or
unusual maternal behavior towards either the F1a or F1b litters such as
rejecting or ignoring the pups. The F1b and F2 pups that were found dead
did have a common finding of no milk present in the stomach. This was
not noted in the F1a offspring; however, it was not specified in the
protocol to examine for the presence of milk in the F1a breeding. There
were no other gross necropsy findings in the offspring that died which
could be indicative of the cause of death.
The reason for the improved viability of F2 offspring is not clear. The
dose response of the viability indices in the F1a offspring is linear
and therefore appears to be a compound effect.
To evaluate the effects of the test substance on gonadal function,
mating behavior and fertility as well as growth and development of
offspring, Sprague-Dawley rats were fed diets containing target dose
levels of 5, 50 and 250 mg/kg of body weight through 2 generations. A
control group received the basal diet only. A second breeding of the
first generation control and high-dose parents with cross-fostering of
some litters was carried out to assess the route of toxicity to
In the high-dose group (250 mg/kg) of both parental generations, body
weights and food consumption were significantly reduced compared to the
concurrent controls. This is considered a treatment effect.
Histomorphologic alterations in the urinary bladder of F0 and F1
parental animals were noted as treatment effects in this group as well.
Reduced pup viability in the high-dose group, particularly in the F1a
generation, was attributed to compound exposure trhough the milk.
Cotnrol pups exposed to the high-dose level of test material by
cross-fostering to high-dose dams also showed reduced viability.
In the mid-dose group (50 mg/kg level), the body weights of parental
rats in the second generation and survival of the first generation of
offspring were slightly lower than the concurrent controls.
Histomorphologic changes were seen in the bladders of F0 males only.
There were no effects of compound exposure on the reproductive
performance of any group. No treatment effects were ween in rats exposed
to the 5 mg/kg dietary level of the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again