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EC number: 907-672-2
CAS number: -
A bioconcentration study of DBPP with Carp was conducted according to
OECD 305E guideline 'Bioconcentration: Flow-Through Fish Test'. Nominal
test concentrations in the water were 0 mg/L (control), 0.005 mg/L (low
concentration) and 0.05 mg/L (high concentration).
At the high concentration level, variation of mean BCFs from three
consecutive measurements at over 48 -hour intervals were within +-20%
and it was considered that steady state was reached. The BCF at steady
state was calculated to be 35.
At the low concentration level, variation of mean BCFs from three
consecutive measurements at over 48 -hour intervals were not within
+-20%.Therefore, a steady state was not considered to have been reached,
and the BCF at steady state was not calculated. Instead, the BCF at this
concentration is presented as a range (20 -54).
Although it is indicated that one of the validity criteria is not met
for the low concencentrations, the results from this bioconcentration
assay can still be regarded as valid and sufficient to draw a conclusion
related to the bioaccumulative potential of DBPP.
Based on the results of this test it can be concluded that DBPP does not
have the potential to bioaccumulate in aquatic organisms.
A bioconcentration study of DBPP (multi-constituent) with Carp was conducted according to OECD 305E guideline 'Bioconcentration: Flow-Through Fish Test' (Kobayashi, 2010). The BCF for DBPP (mono-constituent) at steady state was calculated to be 35. From the results of this key study it can be concluded that DBPP does not have the potential to bioaccumulate.
The available key study (Koboyashi, 2010) is a bioconcentration study
with Carp which was conducted according to OECD 305E guideline. Nominal
test concentrations in the water were 0 mg/L, 0.005 mg/L and 0.050 mg/L
(respectively control, low and high concentration). At the high
concentration level, the BCF at steady state for the mono-constituent
DBPP was calculated to be 35. At the low concentration level, variation
of mean BCFs from three consecutive measurements at over 48 -hour
intervals were not within the specified range (+-20%). Therefore, at the
low concentration a steady state was not considered to have been
reached. Therefore, the BCF at this concentration is presented as a
range (20 -54). Based on the results of this test it could be concluded
that the substance (DBPP) does not have the potential to bioaccumulate.
Additional supporting studies were conducted, based on a QSAR approach
for all three constituents DiButyl Phenyl Phosphate (DBPP), TriButyl
Phosphate (TBP) and Butyl DiPhenyl Phosphate (BDPP):
compound log BCF
DBPP 1.54 (key study)
The QSAR is well described with a clear regression model, a clear
endpoint and all three compounds fall well within the applicability
domain of the QSAR. The QSAR result of DBPP is in good agreement with
the result of the key study and confirms that DBPP has no
bio-accumulation potential. Also TBP and BDPP have no bio-accumulation
The low bio-accumulation potential for DBPP was also confirmed by a
supporting (older) study (Saeger et al., 1979), in which the
bioconcentration factor of DBPP was estimated using a different QSAR
(based on the log Pow). This study did not contain sufficient
information for assessment and was consequently ranged K4 (no indication
of the applicability domain nor error estimates were given).
Nevertheless, also in this study it was indicated that the substance has
a low potential for bioaccumulation (estimated BCF of 270, log BCF 2.43).
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