Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 907-672-2
CAS number: -
The test substance was applied to the shaved backs of 4 female and 4
male rabbits at dosage levels of 10, 100 and 1000 mg/kg/d, 5 days a week
for 3 weeks. The 2 control groups, each composed of 4 male and 4 female
rabbits, received distilled water at a dosage level of 2 mL/kg/d on the
same regimen as the treated rabbits. The rabbits were observed daily.
Individual body weights were recorded weekly. Hematological and
biochemical studies and urinalysis were conducted once in the pretest
period and at 3 weeks of study. At necropsy the cholinesterase activitiy
of the brain was determined for all rabbits.
One male rabbit was found dead on day 3, and one male rabbit was
sacrificed in extremis on day 12 of the study period. Each of these
rabbits were in the 100 mg/kg/d dose group. No changes considered to be
related to the compound were seen in general appearance, body weights,
hematological studies or urinalysis.
At each dosage level, the test substance elicited erythema, edema,
atonia, desquamation, coriaceousness and fissuring on all the rabbits.
For 3 or more rabbits at each dosage level the erythema became marked
and the edema became moderate. Blanching accompanied the erythema for 3
and 8 rabbits in the 10 and 1000 mg/kg/d dosage levels, respectively.
The coriaceousness remained slight at the 10 mg/kg/d dosage levels but
became moderate for 3 and 6 rabbits at the 100 and 1000 mg/kg/d dosage
levels, respectively. At each dosage level the atonia, desquamation and
fissuring became moderate for 1or more rabbits. The number of rabbits on
which these signs of dermal irritation were noted increased with the
For both male and female treated rabbits the mean cholinesterase
activity of the plasma was, with the exception of the 100 mg/kg/d
females in control period, less than that of the control group at the
initiation as well as termination of the study. The differences between
the mean cholinesterase activitiy for the brain of the female rabbits
treated at the 1000 mg/kg/d dosage level and Control group II was
statistically significant. These differences may be biologically
significant, however, no physiological signs of decreased cholinesterase
activity were observed.
All rabbits which were sacrificed at termination or which died during
the study period were necropsied. All rabbits from the 3 experimental
groups had compound-related changes in the skin of the application
sites. Thinkening and fissuring were the most comonly observed lesions.
Other compound-related findings included scabbing, crusting, erythema
Microscopically, compound-related lesions were limited to the skin of
the application site where most rabbits from the 3 experimental groups
had acanthosis and hyperkeratosis. Most rabbits from the 100 and 1000
mg/kg/d groups had dermal edema. Accumulation of necrotic debris was
observed in several rabbits from each experimental group. Parakeratosis,
ulceration and vesicle formation occurred in occasional rabbits from one
or more experimental groups. Increased incidence of lymphoid hyperplasia
in the regional lymph nodes in the 3 experimental groups and
reticuloendothelial hyperplasia of the regional lymph nodes in 2 rabbits
from the 1000 mg/kg/d group were also considered compound-related.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again