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EC number: 907-672-2
CAS number: -
An Ames study was performed to investigate the potential of dibutyl
phenyl phosphate (DBPP) reaction mass to induce gene mutations in the
plate incorporation test (experiment I) and the pre-incubation test
(experiment II) using the Salmonella typhimurium strains TA 1535, TA
1537, TA 98 and TA 100, and the Escherichia coli strain WP2 uvrA.
The assay was performed in two independent exerpiments both with and
without liver microsomal activation. Each concentration, including the
controls, was tested in triplicate. The test item was tested at the
following concentrations in both experiment I and experiment II: 3 - 10
- 33 - 100 - 333 - 1000 - 2500 and 5000 ug/plate.
The plates incubated with the test item showed reduced background growth
in all strains at higher concentrations.
Toxic effects, evident as a reduction in the number of revertants (below
the indication factor of 0,5), occurred in nearly all strains with and
No substantial increase in revertant colony numbers of any of the 5
tester strains was observed following treatment with dibutyl phenyl
phosphate (DBPP) reaction mass at any dose level, neither in the
presence nor absence of metabolic activation mix (S9).
Appropriate reference mutagens were used as positive controls and showed
a distinct increase of induced revertant colonies.
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