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EC number: 231-843-4
CAS number: 7758-94-3
This study was performed (using OECD Guideline No. 402) to assess the
acute toxicity of the test article, iron dichloride (CAS No.: 7758 -94
-3) by single dermal administration to Sprague-Dawley rats. Mortality,
clinical signs and bodyweight changes were monitored throughout the
study. All animals were humanely killed as scheduled and examined
macroscopically on Day 15, the end of the observation period.
Five female and five male rats each received 2000 mg/kg bw as a limit
test. Because there was no mortality observed, the study was completed.
There were no unscheduled deaths and bodyweight gains were normal during
A yellowish-brown change was observed at the application site in all
test animals, and was considered to relate to the colour of the test
article. Two males and 4 females had a reddish nasal discharge on Day 2,
which was considered a distress symptom caused by pressure of taping on
the thorax area.
During macroscopic examination, scarring was observed at the application
site on one male and one female. This was considered to relate to
application of the test article. internally, no abnormalities were
In conclusion, the LD50 to rats of the test article, iron dichloride
(CAS no.: 7758 -94 -3) by a single dermal administration is considered
to be greater than 2000 mg/kg bw under the conditions of this study.
Therefore the substance (iron dichloride) is not classified for Acute
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