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EC number: 231-843-4
CAS number: 7758-94-3
In a pre-GLP study into the respiratory effects of exposure to ferric
sulfate aerosol in humans (reliability score 2) volunteers (38) were
exposed to 75 µg/m3 aerosol for 2 hours on each of 5 days. The investigation was conducted as a 'double blind' study. Subjects served
as their own control by blind exposure to 'sham' aerosol. The group average results were contrasted between day (sham or exposure)
and conditions (pre- and post-exposure) using a two-way analysis of variance with repeated measure.
Only five of the 38 volunteers
tested showed patterns indicative of a decrement in pulmonary function. Nine of the
exhibited significant improvement in function. None of the subjects reported more than slight changes in symptoms during exposure.
The authors considered that the tendency for a
subject to improve after the ferric sulfate exposure could be related to allergy status, smoking history,
or a combination of these factors. Furthermore, they recorded that "it is encouraging to note that at the relatively high aerosol
concentration used in this study, there were no significant decremental changes in the (study) population as a whole." The study appears
to have been well conducted and the conclusions are consistent with the data presented. It may be assumed that ferric sulphate aerosols
do not produce any clear pulmonary effects in either normal persons or asthmatics.
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